In a troubling echo of historical injustices, recent reports have unveiled a controversial series of ivermectin experiments conducted at an Arkansas jail, drawing sharp criticism and raising alarms about the treatment of imprisoned populations, particularly minorities. The experiments, which purportedly aimed to explore the drug’s efficacy against COVID-19, have ignited a fierce debate over ethical boundaries in medical research and the vulnerability of marginalized groups within the prison system. As advocates demand accountability and transparency, the incidents serve as a stark reminder of the dark legacy of medical exploitation in the United States, where the rights of the incarcerated have often been overlooked. This article delves into the implications of these experiments and the broader context of medical ethics, historical abuses, and the ongoing fight for justice.